Study shows lithium chloride blunts brain damage linked to fetal alcohol syndrom – EurekAlert (press release)

A single dose of lithium chloride, a drug used to treat bipolar disease and aggression, blocks the sleep disturbances, memory loss, and learning problems tied to fetal alcohol syndrome, new experiments in mice show.

Published in the journal Neuroscience online Nov. 26, and led by researchers at NYU School of Medicine, the new study found that giving the drug to newborn mice 15 minutes after “binge” alcohol consumption eliminated the hyperactivity and sleep deficits seen when rodents exposed to alcohol became adults. Moreover, the researchers report, lithium chloride-treated mice were much less likely to show the 25 percent drop in memory and cognitive test scores seen in untreated mice given the same amount of alcohol.

“Our study showed that lithium chloride prevented many of the damaging neurological effects of alcohol abuse on the still-developing brain, especially the impact on the parts of the brain controlling sleep,” says co-senior study investigator Donald Wilson, PhD.

Mice given alcohol just after birth are a good model for measuring the impact on human fetal development because the brains of mice pups achieve developmental milestones after birth that are comparable to those in other mammals, including humans.

Wilson, a professor at NYU Langone Health, cautions that it is too early to propose lithium chloride as a treatment or preventive therapy for fetal alcohol syndrome. The drug is “likely far too risky for pregnant mothers,” with known organ toxicities, he says. Further experiments would have to proceed under strict medical supervision to ensure the safety of mothers and children.

A more likely future therapy, says co-senior study investigator Mariko Saito, PhD, would be one that takes advantage of chemistry related to the action of lithium chloride, but with fewer side effects. “Lithium chloride is known to block many pathways that lead to brain cell death,

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